Chronic Wound Repair and Management

Diabetic wounds are classified as chronic and non-healing due to their permanent stasis in the inflammation phase. This is due to the stunted and incomplete healing process brought about by the dual unifying mechanisms of hyperglycemia and oxidative stress. Current FDA-approved therapeutics for diabetic wounds have been met with limited success rates due to their inability to consider and address the diabetic microenvironment in its entirety. We are focused on developing tailored treatment options for diabetic wounds through electro-spun nanofibers matrices that are equipped to not only mimic the in-vivo biological support matrix, but also elicit physiochemical cues that can manipulate and activate pro-healing targets in the chronic milieu.